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Tamsulosin er 0.4 mg capsule extended release 24 hr and 12 hours). The dose was titrated up to a maximum of 3mg/kg/week. Adverse reactions were observed in two patients, who were treated with Tamsulosin (20 mg in 1.5 ml of saline) and one who received Tamsulosin, but not extended release, as an adjunct drug to Tamsulosin.
Tamsulosin was well-tolerated except for two patients with anaphylactic reactions (all but one died) (Table 3). A postmarketing study in healthy volunteers has previously shown that Tamsulosins were effective in reducing pain (9). However, there was no change in self-reported pain scores and there was no comparison to placebo. One hundred sixty-three patients completed the study and showed statistically significant increases in self-reported pain scores with Tamsulosin. The efficacy in a retrospective cohort study migraine headache is inconsistent [see Clinical Studies (14)].
Table 3. Common Adverse Reactions in Headache Trial of Tamsulosin
In all of these studies, Tamsulosin was well-tolerated with an incidence of 2.7% for Tamsulosin, 1.1% Tamsulosin with extended release, and 1.2% for placebo.
Table 4. Adverse Reactions in Two-year Headache Trial of Tamsulosin
In Tamsulosin patients, five (1.3%) patients discontinued treatment due to any reason. Allergies occurred more frequently in the Tamsulosin treatment group (10%), followed by headache (1%). In the Tamsulosin-exposed group, 12% had a change of use from the first month of treatment to the second month because of adverse reactions (including discontinuations). The two most common adverse reactions in the Tamsulosin-exposed group were nausea and vomiting (Table 4). A total of 24 (18%) patients discontinued Tamsulosin due to adverse reactions, whereas in the online pharmacy uk delivery total population (n=39), 5 (2%) patients discontinued treatment. Only one patient on Tamsulosin discontinued Tamsulosin, the patient, due to an adverse reaction (n=1).
In the double-blind study migraine, first 3 months of Tamsulosin were compared with placebo (12 patients treated Tamsulosin, compared with 27 patients treated placebo):
2.8% (3 of 12) patients treated with Tamsulosin stopped because of adverse reactions, compared to 0.7% of patients in the placebo group (P=0.06) (Figure 1).
The most common adverse reactions found in Tamsulosin-treated patients were headache (2.8%) and nausea (2.7%), followed by vomiting (1.9%).
In the double-blind study migraine, first 3 months of Tamsulosin were compared to
tamsulosin hydrochloride mr 400 mcg capsules an active control:
2.8% (2 of 12) Tamsulosin-treated patients stopped Tamsulosin because of adverse reaction, compared to 1.2% of placebo (P=0.01) (Figure 1).
The most common adverse reactions found in Tamsulosin-treated patients were headache (2.8%) and nausea (2.7%), followed by vomiting ()
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